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Istradefylline forty mg/day enhanced peak levels and AUC of CYP3A4 substrates in scientific trials. This result was not observed with istradefylline twenty mg/day. Take into consideration dose reduction of delicate CYP3A4 substrates.Inhibition of platelet aggregation by clopidogrel is completely as a result of an Energetic metabolite. Clopidogrel i